Hormones, Metabolism & the Truth About GLP-1s
A Conversation with Dr. Caroline Messer
Have you ever felt like your body changed on you overnight?
Your energy is different. Your weight feels harder to manage. Your sleep is off. Your mood does not feel like your own. And you catch yourself wondering, "Is this just life now, or is something actually going on inside my body?"
On this episode of Inside the Wellspace, Cathy O'Brien sits down with one of the leading experts in that exact question: Dr. Caroline Messer.
Dr. Messer is a double board-certified clinical endocrinologist, co-founder of Fifth Avenue Endocrinology, and founder of Well by Messer, a multi-specialty group with offices across New York and Connecticut, and Florida on the way. She trained at Yale and Mount Sinai, has been named a Castle Connolly Top Doctor year after year, received the Exceptional Women in Medicine Award since 2019, and serves as the endocrinologist for the New York Knicks, the Rangers, and the Liberty.
In this conversation, Cathy and Dr. Messer unpack the hormone system that quietly influences almost everything in the body:
What endocrinology actually is, and why hormones are the "control center" for metabolism, mood, bone health, reproduction, and sleep
How to know when symptoms like fatigue, weight changes, low libido, anxiety, or brain fog might be hormone-related
The overlap between endocrinology and other areas like menopause care, thyroid health, fertility, and bone density
The truth about GLP-1 medications, hormone replacement therapy, and osteoporosis screening
How to navigate the tidal wave of misinformation online and advocate for yourself in a medical setting
What makes this episode special is not just Dr. Messer's credentials, but how human and grounded she is in the way she explains complex science. She talks with real empathy about what patients are going through, and why endocrinology is not a luxury or "extra testing" but a key part of understanding how the body works together.
If you are moving through a new season of life, dealing with symptoms that do not seem to have clear answers, or you simply want to understand your health on a deeper level, this conversation will give you language, clarity, and a place to start.
Tune in to hear Cathy O'Brien and Dr. Caroline Messer talk about hormones, whole-person health, and what is actually possible when you finally get the right kind of support.
🔗 Connect with Dr. Messer:
🌐 Website: https://endocrineonfifth.com/
You can watch or listen to the episode on Youtube, Apple Podcasts, and Spotify.